One Southern Indiana would like to thank the following businesses that renewed their membership during the month of December 2021.
| Quarter Century Club (25 Year or More) | Member Since |
| Indiana-American Water Company | 1967 |
| DMLO – New Albany | 1972 |
| PC Home Center | 1978 |
| Libs Paving Co., Inc. | 1990 |
| USI Insurance Services, LLC | 1994 |
| WesBanco Bank, Inc. | 1994 |
| Ten to 24 Years | |
| Ameriguard Storage Center | 1998 |
| Combs Heating & Air Conditioning LLC | 1998 |
| Hope Southern Indiana, Inc. | 1998 |
| Mane Event Decorators | 1998 |
| Wiggam Lumber, Inc. | 1999 |
| Smith Creek, Inc. | 2001 |
| One Vision Credit Union | 2002 |
| Business Health Plus, Inc. | 2003 |
| Christian Academy of Indiana | 2004 |
| LL&A Interior Design | 2005 |
| Mediaura | 2008 |
| Theresa J. Lamb Insurance Agency, Inc. | 2009 |
| Five to Nine Years | |
| Big Brothers Big Sisters of Kentuckiana | 2016 |
| Hampton Inn by Hilton New Albany Louisville West | 2016 |
| Mathes Pharmacy & Homecare | 2016 |
| Zaxby’s – Charlestown Rd. | 2016 |
| W.M. Kelley Company, Inc. | 2017 |
| BJB Inc. | 2017 |
| A. Rutz Law, LLC | 2017 |
| Two to Four Years | |
| A Class Act DJ’s | 2018 |
| Red Roof Inn – Georgetown | 2018 |
| Tree of Life Family Birth Center | 2018 |
| Heine Brothers’ Coffee | 2019 |
| Excel Excavating, Incorporated | 2020 |
| Homeless Coalition of Southern Indiana | 2020 |
| That’s My Dog | 2020 |
| One Year | |
| BelFlex Staffing Network | 2021 |
| FranNet of of Kentucky & Southern Indiana | 2021 |
| ImmunoTek Bio Centers, LLC | 2021 |
| Magnet Culture | 2021 |
| Mitch Craig Heating & Cooling of New Albany | 2021 |
| Penny Tracker | 2021 |